‘We demonstrated a role for the chemokine receptor CX3CR1 in microglial neurotoxicity in three clinically relevant models: CNS response to systemic inflammation, the MPTP model of Parkinson disease, and the SOD1 model of ALS. Based on complementary expression of CX3CL1 on neurons and CX3CR1 on microglia, it has been proposed that neuron signaling to microglia might be mediated through this receptor.’
How awesome I can’t help think it is:
‘Excitotoxic injury is a potent stimulus for release of CX3CL1 from cultured neurons, CX3CR1 supports neuronal survival, microglia culutred with CX3CL1 are protected from Fas-mediated apoptosis, and CX3CL1 suppresses neuronal cell death in LPS- and IFN-gamma-stimulated microglial and neuronal cocultures.’
Absolutely fantastic. Who would have known, coming from this unique chemokine, now I want to know more about this fabulous glycoprotein.
Tomorrow.
OK, let’s just finish off this talk by saying that augmenting (INCREASING) CX3CR1 singaling is a good thang!
I also had one hour break to test run my new jogging shoes.
more sky pics on display one at a time above – these were from tonight very cold, but went out at 9pm to run, a bit late